Dr. Jillian Kurtz discussed ovulation induction.
40: Aneuploidy - Part 2
Join me as we finish our discussion on anueplody screening. In this episode we discuss the risks of amniocentisis and chorionic villus sampling, cell-free DNA, and different screening strategies.
Comparing Different Strategies
Amnio/CVS
PRENATAL DIAGNOSIS IN MULTIPLE GESTATION: 20 YEARS’ EXPERIENCE WITH AMNIOCENTESIS
Fetal Complications of Amniocentesis
Intrauterine diagnosis and management of genetic defects
Role of Amniocentesis in the Intrauterine Detection of Genetic Disorders
Needle puncture of fetus: A complication of second- trimester amniocentesis
Fetal loss rate after chorionic villus sampling
and amniocentesis: an 11-year national registry study
Procedure-Related Complications of Amniocentesis and Chorionic Villous Sampling
Analysis of 2136 genetic amniocenteses: Experience of a single physician
Midtrimester amniocentesis: An analysis of 923 cases with neonatal follow-up
Cell-Free DNA
Presence of fetal DNA in maternal plasma and serum
Increased Fetal DNA Concentrations in the Plasma of Pregnant Women Carrying Fetuses with Trisomy 21
Fetal DNA in maternal plasma is elevated in pregnancies with aneuploid fetuses
Noninvasive Prenatal Detection of Aneuploidy
Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection
39: Monthly Checkup - August 2018
Join us for a discussion on sexism in medicine, STD screening for women diagnosed with PID, and the removal of the Essure device from the market.
Feedback@obgyn.fm
Sexism in Obstetrics & Gynecology: Not just a “women’s issue”
HIV and Syphilis Screening Among Adolescents Diagnosed With Pelvic Inflammatory Disease
Bayer Will Stop Selling the Troubled Essure Birth Control Implants
38: Interview with Dr. Quirk
In this episode we talk with Dr. J. Gerald Quirk about his efforts to start a state wide AFP screening program in Arkansas in the 1980s.
obgyn.fm
37: Monthly Checkup - July 2018
Dr. Ballas and Dr. Lian join us to discuss three great topics.
1. Social structure of the operating room
36: Journal Club - July 2018
I am joined by minimally invasive gynecologic surgeons Dr. Blaber and Dr. Lian to discuss a paper from the May issue of AJOG.
Uccella S, Malzoni M, Cromi A, et al. Laparoscopic vs transvaginal cuff closure after total laparoscopic hysterectomy: a randomized trial by the Italian Society of Gynecologic Endoscopy. Am J Obstet Gynecol 2018;218:500.e1-13.
35: Monthly Check-up - June 2018
In this episode Dr. Sara Kim and Dr. Jillian Kurtz join me to discuss some basic research papers about pregnancy dating and PCOS.
Noninvasive blood tests for fetal development predict gestational age and preterm delivery
34: Aneuploidy - Part 1
In this episode we trace the history of aneuploidy screening from the early days of amniocentesis to the modern day serum screening.
feedback@obgyn.fm
1987 Cuckle Paper:
Other references in no particular order:
First-Trimester or Second-Trimester Screening, or Both, for Down’s Syndrome
SOMATIC CHROMOSOMES IN MONGOLISM
Contingent screening for Down syndrome completed in the
First trimester: a multicenter study
Antenatal maternal serumscreening for Down's syndrome: results of a demonstration project
Low second trimester maternal serum unconjugated oestriol in pregnancies with Down's syndrome
Low second trimester maternal serum unconjugated oestriol in pregnancies Down's syndrome
Fetal nuchal translucency: ultrasound screening for chromosomal defectsinfirsttrimesterofpregnancy
Maternal serum screening for Down's syndrome in early pregnancy
Combining maternal age and serum alpha-fetoprotein to predict the risk of Down syndrome
Appropriate Biochemical Parameters in First-trimester Screening for Down Syndrome
Screening in early pregnancy for pre-eclampsia using Down syndrome Quadruple test markers
33: Monthly Check-up - May 2018
In this episode Dr. Ballas and I discuss the declining US birth rate and paretnal leave for ob/gyn residents.
32: Oncofertility and fertility preservation
In this episode Dr. Jillian Kurtz walks us through the methods and rationale behind fertility preservation for patients with cancer or undergoing transgender procedures.
31: Journal Club - May 2018
In this episode I am joined by Dr. Ballas and Dr. Kim to discuss the paper "Pregnancy Exercise and Nutrition With Smartphone Application Support" from the May edition of Obstetrics & Gynecology.
Pregnancy Exercise and Nutrition With Smartphone Application Support: A Randomized Controlled Trial
30: The Monthly Checkup - April 2018
In this episdoe we discuss the new postpartum guidelines from ACOG, newborn microbiome seeding, and the gentle cesarean.
ACOG Committee Opinion: Optimizing Postpartum Care
ACOG Committee Opinion: Vaginal Seeding
OBG Management: Gentle Cesarean
29: Journal Club - April 2018
In this episode we discuss the mode of delivery in twin gestation
Paper:
feedback@obgyn.fm
Other References:
- Association Between Planned Cesarean Delivery and Neonatal Mortality and Morbidity in Twin Pregnancies
- How singleton breech babies at term are born in France: a survey of data from the AUDIPOG network
- Twin Birth Study: 2-year neurodevelopmental follow-up of the randomized trial of planned cesarean or planned vaginal delivery for twin pregnancy
28: PCOS - Part 2
In this episode we finish up PCOS by discussing the management and long-term consequences.
- Polycystic ovary syndrome: etiology, pathogenesis and diagnosis
- Combined oral contraceptives in the treatment of polycystic ovary syndrome
- Ovarian Suppression in Normal-Weight and Obese Women During Oral Contraceptive Use: A Randomized Controlled Trial
- Ovulation incidence with oral contraceptives: a literature review
- Shorter pill-free interval in combined oral contraceptives decreases follicular development
- Comparison of efficacy of metformin and oral contraceptive combination of ethinyl estradiol and drospirenone in polycystic ovary syndrome
- Evidence-Based and Potential Benefits of Metformin in the Polycystic Ovary Syndrome: A Comprehensive Review
- Metformin, oral contraceptives or both to manage oligo-amenorrhea in adolescents with polycystic ovary syndrome? A clinical review
- Additive Effects of Insulin-Sensitizing and Anti-Androgen Treatment in Young, Nonobese Women with Hyperinsulinism, Hyperandrogenism, Dyslipidemia, and Anovulation
- Metformin and gonadotropins for ovulation induction in patients with polycystic ovary syndrome: a systematic review with meta-analysis of randomized controlled trials
- Aromatase inhibitors for subfertile women with polycystic ovary syndrome: summary of a Cochrane review
- Epidemiology, diagnosis and management of hirsutism: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome Society
- Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis
- Lifestyle Modification Programs in Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis
- The Impact of Bariatric Surgery on Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis
- Assessment of Cardiovascular Risk and Prevention of Cardiovascular Disease in Women with the Polycystic Ovary Syndrome: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society
- Body Composition Is Improved During 12 Months' Treatment With Metformin Alone or Combined With Oral Contraceptives Compared With Treatment With Oral Contraceptives in Polycystic Ovary Syndrome
- Influences of weight, body fat patterning and nutrition on the management of PCOS
27: The Monthly Checkup - November 2017
In this Months Checkup Drs. Ballas and Kim join me to discuss the link (or non-link) between acetaminophen use during pregnancy and ADHD, the new NIH funded PregSource initiative, and how we architecture affects how we provide care.
26: Antenatal Steroids - Part 2
In this episode Dr. Øystein Bergøy discusses the evidence behind the risks of antenatal corticosteroids for women at risk for preterm delivery.
- ACOG guidelines on fetal maturation
- NICE guidelines on risk of premature labour
- Norwegian guidelines on risk of premature labour
- 2015 cochrane analysis of repeat steroids
- Study were microsimulation was used to make a ratio of benefits vs harms of repeat steroids according to gestational age at birth
- Uptodate.com article on antenatal steroids
- study showing increased rds 1 to 24 hrs after booster dose
- Review from Nature in 2001 mentioning several animall studies that show negative effects of excess corticosteroids in utero
- Animal study from Kidney Int from 2000 showing increased risk of glucose intolerance with exogenous corticosteroid exposure in utero
- Study in baboons from Nature in 2012 showing impaired myelination after exposure to repeat antenatal steroids
- 3 studies that have shown impaired stress response inneonates exposed to antenatal steroids
- https://www.ncbi.nlm.nih.gov/pubmed/?term=Antenatal+betamethasone+administration+alters+stress+physiology+in+healthy+neonates
- https://www.ncbi.nlm.nih.gov/pubmed/?term=Effects+of+prenatal+betamethasone+exposure+on+regulation+of+stress+physiology+in+healthy+premature+infants
- https://www.ncbi.nlm.nih.gov/pubmed/?term=Neonatal+adrenal+function+after+repeat+dose+prenatal+corticosteroids%3A+a+randomized+controlled+trial
- https://www.ncbi.nlm.nih.gov/pubmed/?term=Multiple+courses+of+antenatal+corticosteroids+and+outcome+of+premature+neonates.+North+American+Thyrotropin-Releasing+Hormone+Study+Group
- Study showing impaired HPA function in children 6-11 years of age exposed to antenatal steroids
- Study showing signs of glucose intolerance in participant who received antenatal steroids compared to placebo
- Study showing increased aortic stiffness in those exposed to antenatal steroids
- crowther et al mid childhood neurocgognitive development
- meta analysis from 2016 in BMJ examining benefits and harms of antenatal steroids between 34 and 36 weeks gestation
25: Antenatal Steroids - Part 1
In this episode Dr. Øystein Bergøy discusses the evidence behind antenatal corticosteroids for women at risk for preterm delivery.
Uptodate articles on RDS
2013 cochrane analysis on type of steroid and regimens
2017 cochrane analysis of antenatal corticosteroids for accelerating fetal lung maturation
2015 cochrane analysis of repeat antenatal corticosteroids
Study from EPICE looking at effects of steroids and time to delivery
ACOG guidelines on fetal maturation
24: Journal Club - September 2017
In this episode Dr. Kim joins me to discuss an article about postplacental IUD placement from the American Journal of Obstetrics and Gynecology.
Postplacental intrauterine device expulsion by 12 weeks: a prospective cohort study
23: The Monthly Checkup - August 2017
Please consider giving to www.breac225.org to help support the victims of Hurricane Harvey.
In this episode we discuss the link between baby powder and ovarian cancer, the effect of breastfeeding on endometriosis, and the long term emotional effect of mode of delivery.
22: PCOS - Part 1
In this episode we trace the history of polycystic ovarian syndrome, learn about the underlying physiology, and how to diagnosis it.
Diagnostic Criteria for Polycystic Ovary Syndrome: Pitfalls and Controversies
Secretion of Androgens by the Polycystic Ovary and its Significance
Defective Biosynthesis of Ovarian Steroids in the Stein-Leventhal Syndrome
Functional Studies of Aromatase Activity in Human Granulosa Cells from Normal and Polycystic Ovaries
Polycystic ovary syndrome: etiology, pathogenesis and diagnosis